Novel Method Of Producing Human Cartilage from Stem Cells Developed by Montana Researchers
Researchers report the discovery of a novel means of artificially generating human cartilage for the human head and neck.
The Debrief 8:09 pm on April 10, 2024
A team of researchers from the University of Montana has developed a novel method of producing human cartilage using stem cells. The discovery could benefit individuals suffering from degenerative joint diseases and craniofacial defects. The researchers used neural crest cells to create organoids, which are small lab-grown versions of organs that replicate their key functions. By analyzing gene expression patterns and cell signaling pathways, they were able to unravel the communication mechanisms between stem cells during their transition into cartilage. However, using artificial sources of cartilage poses a challenge due to potential rejection by the human body, necessitating the use of immunosuppressant drugs.
- Researchers at the University of Montana have developed a new method of producing human cartilage from stem cells.
- They utilized neural crest cells to create organoids, which helped unravel how stem cells communicate during their initial stages to become cartilage.
- The researchers analyzed gene expression patterns and cell signaling pathways to understand the human-specific differentiation mechanism.
- Using patient-derived stem cells for transplant surgeries remains a challenge due to potential rejection and the need for immunosuppressant drugs.
- Findings were published in the journal iScience.
https://thedebrief.org/novel-method-of-producing-human-cartilage-from-stem-cells-developed-by-montana-researchers/